Empty Capsule

For over 2 decades, SaintyCo has invested in R&D to produce high quality empty capsules that are consistent with the current Good Manufacturing Practices (cGMP) requirements.

The company has also filed a Drug Master File (DMF) with the FDA, besides working closely with other auditing firms in the pharmaceutical industry to ensure safety of all its capsules.

At the moment, SaintyCo provides a one-stop-solution for all empty capsule needs in the global market. This includes 20 different countries in the 5 continents.

The empty capsules are available in different sizes from 00, 0, 1, 2, 3, 4 to 5. Also available are the different printing options such as the multi-colored and oriental options.

The Advantages

  • Suitable for both low and high speed encapsulating machines
  • Safe as per the FDA standards
  • Durable, hence good for long-term storage
  • Stable with a minimal change in length, weight and moisture absorption
  • A wide range of color printing options available such as axial, radial, multi-color or spin
  • Accurate sizing and color matching

Gel-Caps Gelatin Capsule 100% bovine

Gel-Caps Gelatin Capsule 100% bovine hide gelatin

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Empty Capsule: The Ultimate FAQ Guide

This guide has all answers on any question you may have on empty capsules.

Whether you want to learn more about ingredients, manufacturing process, quality control or filling process, you will find everything here.

Let’s get to it:

What are Empty Capsules?

Empty Capsules

 Empty capsule

These are capsules that have not been filled with any formulation.

They are either hard gelatin or two-piece capsules.

When the drug has an unpleasant smell or taste, capsules can be used to mask it.

Also, you could use empty capsules when the drug texture cannot be put in tablet form.

The empty capsules content must be a dry powder because gelatin disintegrates when it comes into contact with water.

Why Buy Empty Capsules?

There are several reasons for buying empty capsules.

First of all, you may do so because it is cost-effective than buying already filled capsules.

When you fill empty capsules, you will be sure of what is in the capsules rather than when you buy them.

The content may be different from what is labeled on it.

You may desire to produce capsules that can be used by patients who are sensitive to proteins or not.

Buying empty ones will allow you to get vegetarian capsules and gelatin capsules separately.

Capsules can be used in storing powder supplements, which are not easy to find.

These are rarely available in capsule form.

Buying empty capsules will allow you to buy the right.

For example, you may need acid resistant empty capsules that allow the release of a dose at a given time.

Buying empty capsules can also allow you to buy customized capsules with your logo and other information printed on it.

This gives an identity to your products and makes them look appealing.

How do you Fill Empty Capsules?

Filling of empty capsules can be done through three different types of capsule filling machines.

You can use manual, semi-automatic, and automatic equipment.

Let me illustrate how these three methods can be used to fill empty capsules.

Capsule filled with different products

Capsules filled with different products

a) Manual Capsule Filling

Manual filling of capsules may go through different processes depending on the design and configuration of the machine.

But generally, it involves the following processes:

Manual capsule filling machine

Manual capsule filling machine

You have prepared the right formulation you intend to store in the capsules before embarking on the filling process.

Put the capsules in the machine and ensure they are all held at the right angle and position.

After locking the capsules, separate them using your hand.

Make sure the body of the capsules is at the same level as the machine filling nozzle.

This is because unequal levels may lead to wastage of materials, and this means a loss in production.

The next step is to pour the powder or granules on the filling surface and tap gently.

Monitor as the products fills every capsule.

After all, capsules have been filled, remove all the extra powder from the filling surface.

Return the tray containing the capsule caps and gently press it on the filled capsules to cover them all.

You can now go ahead and remove the capsules from the machine.

Inspect if they all meet the quality standards and requirements.

b) Semi-automatic Filling Machine

This is a filling machine that is automated to some extent.

Filling of capsules using this machine involves the following process:

Semi automatic capsule filling machine

 Semi-automatic capsule filling machine

First, you need to load the machine with both the product and the empty capsules.

This type of filling technique has the space for both empty capsules and the formulation.

Switch on the machine so that the disc can begin to rotate.

As the disc rotates, the machine automatically fills the capsules into their respective holes in readiness for filling.

After aligning them, lift the upper part of the rotating disc to separate the capsule cap from the body.

This can only be done manually since the machine cannot do so.

This is what qualifies this machine as a semi-automatic type.

Thereafter, fill all the empty capsules with the formulation automatically as the disc continues to rotate.

The filling processes through this machine are much accurate and consistent.

The disc will rotate and return to the initial position.

The rotating disc upper section is returned so that the second rotation is used to cap filled capsules.

The semi-automatic machine will automatically replace the caps in the body of capsules, thereby sealing them completely through compression.

The filled capsules will, thereafter, relocate to the discharge chute where they will eventually leave the machine.

You can now conduct capsule quality tests and see if they are of good quality.

c) Fully Automatic Capsule Filling Machine

This type of capsule filler operates faster, accurately, and cost-effective than both manual and semi-automatic ones.

They are ideal for high capacity and larger productions.

Two main capsules filling machines that are fully automated are the dosator and tamping pin capsule filler.

· Tamping Pin Capsule Filling

First of all, load the formulation into the machine.

The machine then automatically orients the capsules to get ready for filling.

Tamping pin system

Tamping pin system

The empty capsules shift from the hopper through a vacuum system and separate them for filling.

When the machine is turned on, the dosing disc begins to rotate.

The continuous circular rotation of the dosing disc facilitates the flow of powder into the filling station holes.

The material is compressed as it moves from the 1st-5th stage through a tamping pin, thereby creating more space.

Thereafter, the extra products are scraped off to ensure accurate, smooth, and consistent filling of capsules.

The rotating turret will facilitate the movement of capsules to the capping station for covering.

The extra materials then move back to the product hopper and eject the capsules to the discharge chute.

· Filling Empty Capsules using Dosator Machine

Dosator capsule filling system

Dostor capsule filling system

This machine is ideal for capsules with low weight.

Instead of the rotating disc in the tamping pin, the dosator has a rotating nozzle.

One tip discharges into the empty capsules while the other dips into the material bed and this happens continuously.

Completely processed capsules are ejected through the discharge chute.

What is Empty Capsules Sizes?

This is the size of the capsules before they are filled.

The sizes may vary depending on the dimensions, weight, and volume it is expected to contain.

Another determinant of capsule size is the formulation and the requirement of a dose.

The empty capsule size is available in the following sizes: 000, 00, 0, 1, 2, 3, 4, and lastly 5.

The 000 size is the largest, while size 5 is the smallest.

Capsules sizes

Capsules sizes

How much can Empty Capsules Hold?

Empty capsules can hold different quantities of formulations.

The quantity will depend on the dimensions of the empty capsules.

Those with larger dimensions can hold relatively large quantities, whereas those with a smaller dimension will hold small quantities.

Different sizes of capsules hold different volumes of formulations.

For example, size 000 has a capacity of 1.37ml, size 00E can hold 1.00ml, and size 00 has a capacity of 0.9ml.

Size 0E holds 0.78ml, size 0 has a capacity of 0.68 and size 1 can hold 0.48ml.

The small sizes like size 2, 3, 4 and 5 holds 0.36ml, 0.27, 0.20 and 0.13ml respectively.

How do you Choose Empty Capsules Filler?

Choosing an empty capsule filler is a very crucial activity.

You cannot choose a good machine without a better knowledge of what a good machine should look like.

Therefore, there are specific quality standards that can help you in choosing an accurate, efficient, and durable machine.

Capsule fillers

 Capsule fillers

You should consider the following:

The machine should be made in compliance with cGMP and FDA.

This states that the materials for making it should be of high quality from stainless steel.

This material should be easy to clean and maintain and must handle dust properly to reduce environmental pollution.

This equipment must adhere to environmental compliance regulations.

For example, produce less noise while in operation, should be cheap and must have a stable system for cooling.

It should also produce less waste to help lessen environmental pollution.

The equipment should be validated to be sure you are choosing the right one. This can be done through the following procedures.

The design of the machine should be verified through a document.

This document should show that it has been made in adherence to the manufacturing quality standards.

Also, the process of installing the equipment should be documented.

You should strictly install it according to the manufacturer’s recommendation.

The operation of the machine should also be validated.

As it operates, look at the operation range and see if it works according to what has been documented.

A document stating how the machine should operate under some specific routine conditions for production should be available.

Here, ensure the operation is reliable, can be repeated, and can be controlled easily.

Apart from these, you can also consider factory acceptable test capsule filling machine and capsule filler user requirement specifications.

Can you get Soft-gel Empty Capsules?

Softgel capsules

 Softgel capsules


There are no empty soft-gel capsules because they are made and filled at the same time with the same machine.

Soft-gel is capsules with only one piece, and therefore, their manufacture goes along with their filling.

So it’s impossible to find soft-gel empty capsules.

Where can you Buy Empty Capsules?

You can buy them at SaintyCo since they manufacture high quality and good empty capsules.

This company sells gelatin, vegetable, or acid-resistant capsules.

In addition to these, SaintyCo produces a wide range of sizes and colors of capsules.

Apart from these, customized empty capsules that have printed logo and product units are also available in SaintyCo.

How do Vegetable Empty Capsules compare to Gelatin Empty Capsules?

There are many differences between vegetable and gelatin empty capsules. For example,

Vegetable capsules are made from plant materials and are therefore ideal for vegetable consumers.

Vegetable empty capsules

Empty vegetable capsules

On the contrary, gelatin capsules are made from animal products like collagen and are therefore good for animal product consumers.

Most semi-solid and gel formulations are stored in empty vegetable capsules, while powder formulations are stored in gelatin ones.

Vegetable empty capsules are relatively expensive as compared to the much cheaper gelatin ones.

In addition to these, vegetable capsules can be used by both vegetarians and those who consume animal products.

This is because they have no effects like an allergy.

On the contrary, gelatin capsules can only be used by consumers who cannot negatively react to animal products.

Empty gelatin capsules

Empty gelatin capsules

Can Empty Capsules Hold Liquid and Semi-solid Products?

Yes, some types can.

For instance, empty vegetable capsules are used to hold both the gel and semi-solid formulations.

Gelatin is not suitable for such because liquids form holes on the gelatin capsules, and this may result in leakage.

How do you Manufacture Empty Capsules?

Empty capsules can be manufactured in a step-by-step process.

The whole process has six different stages.

Let me shade more light on these stages of manufacturing capsules:

Empty capsules manufacturing process

Empty capsules manufacturing process

First stage: This stage involves the preparation of the empty capsule materials.

Choose high-quality materials for either gelatin or vegetable capsules.

The materials will go through melt, boil, or mixing of the material ingredients depending on the process requirements.

Second stage: At this stage, add dye and opercifants.

These additions will also be influenced by the empty capsule requirements.

Third stage: Load the materials into the machine, and either pumps them or allow them to move in the machine by gravity.

This will be determined by the design of the machine.

Fourth stage: This is the stage where capsules are molded.

The liquid materials are shifted to the capsule shell-forming stage.

The machine then molds the capsules into the required shape and size.

Different configurations of the machine will enable it to form capsules with cylindrical shapes.

The capsules will be dried by controlling their humidity, temperature, and air volume.

The fifth stage: This is the stage where empty capsules that have been dried are discharged.

The two halves of the capsules are stripped from the pin bars.

This facilitates the ease of joining back the capsules back after filling them with products.

The gelatin made capsules are also trimmed at this stage.

Also, the machine will, at this stage, control the size, moisture content, thickness, and color of the capsules.

The sixth stage: At this stage, the capsules are inspected for any defects.

This is done to make sure the capsules are made in conformity to the required quality standards.

Remember, every stage in hard gelatin capsule manufacturing process requires strict control of process parameters.

How should you store Empty Capsules?

Empty capsules, like any other product, deserve proper storage to maintain their quality.

Improper storage may cause damage to them, and this may render them useless for holding products.

For this reason, maintaining the shape, color, and condition of the capsules requires you to consider the following storage measures.

  • The empty capsules should be stored in the original packing since this is safe for them.
  • The temperature range for the room where they are stored should be between 15 degrees to 25 degrees Celsius.
  • The relative humidity should remain in a range from 35% to 65%.
  • You should avoid high or cyclic temperatures.
  • Ensure you keep the empty capsules away from steam, sunlight, or hot water.

Improper storage of empty capsules may distort their shape, shatter them, and make the separation process very difficult.

When all these storage regulations are adhered to, empty capsules may have a shelf life of about five years.

If storage is compromised, they will have a relatively less shelf life.

What are the best Empty Capsules for Semi-solid and Liquid Products?

The best empty capsules for semi-solid and liquid product formulations are empty vegetable capsules.

Gelatin is not ideal because the liquid creates holes in it, and the liquid may begin to leak.

This may eventually lead to the breakage of the capsule.

Alternatively, there is an advanced technology known as Liquid-filled hard capsules (LFHC).

It is available in both gelatin and hypromellose (HPMC).

It is suitable for liquid, semi-solid, paste, and multi-particulate applications.

LFHC protects the formulation form leaking through gelatin.

It is also airtight and is one of the encapsulations that are impermeable to moisture, oxygen, and light.

How do you Specify Empty Capsules?

Two piece capsules

 Two piece capsules

There are many ways of specifying empty capsules.

These include:

  • The type of material that has been used to manufacture the capsules. These could be either gelatin or vegetable materials.
  • You can also specify them through their flavor, dye, pigment, and any other ingredient that must have been used.
  • It is critical to look at the quality standards and compliance. These include USP, FDA, and I.P. 1996.
  • In addition to these, you can also specify them through their size and dimensions. The sizes may include 000, 00, 0, 1, 2, 3, 4, and 5. The 000 sizes being the biggest while size 5 is the smallest.
  • Empty capsules can also be specified through their weight and volume.
  • Another way of specifying empty capsules is by considering the time it will take to disintegrate. Some take a longer time as compared to others.
  • Lastly, it is very critical to know the manufacturer of the empty capsules. Some of them manufacture only gelatin while other processes only vegetable capsules. But fortunately, others may manufacture both gelatin and vegetable in different sizes and shapes.

What is the difference between Hard Gelatin Capsules and Soft-gel Capsules?

Softgel capsules

 Softgel capsules

Hard gelatin capsules

Hard gelatin capsules

There are many differences between hard gelatin and soft-gel capsules.

For example, hard gelatin capsules are manufactured from hard gelatin, whereas the soft-gel ones are manufactured from soft gelatin/ribbon material.

Soft-gel is available in one piece that is hermetically sealed.

On the other hand, the hard gelatin capsules are available in two separate pieces.

This allows for easy opening of capsules for filling purposes and capping them later.

Gelatin capsules are ideal for holding powder products, while soft-gel is good for gel or oil-based materials.

The manufacturing and filling process of gelatin capsules requires the use of two different machines.

That is an empty capsule manufacturing machine and capsule filling machine.

On the other hand, forming and filling process of soft-gel capsules is done using one machine as one process.

Gelatin capsules are made in a cylindrical shape, whereas soft-gel capsules come in different shapes.

The shapes may be round, fish-like, oval, or tube-like.

The ration of gelatin to plasticizers in gelatin capsules in 1:0.4.

On the other hand, the ratio of gelatin to plasticizers in soft-gel capsules is 1:0.8.

Are two-piece Capsules Safe?

Yes, they are since they are 100 percent natural and contain no animal or wheat preservatives.

This is because they are made from vegetable cellulose, and we all know that vegetable does not affect.

Therefore, it’s ideal for everyone, including those that have some animal protein allergies.

There could be a risk of leakage, which may lead to less than expected capsule content.

This may result in patients taking less dose, and this is dangerous.

However, mitigation plans like sourcing high-quality capsules and formulating the product to be more viscous could be applied.

Which Ingredients are used to make Empty Capsules Shell?

There are many ingredients used in manufacturing empty capsules.

The specific empty capsule you intend to make will influence the types of ingredients you will use in making them.

Hard gelatin capsules shells are made from collagen, which is extracted from animal products.

Plant products like cellulose are used to make vegetable capsules.

Other ingredients used are plasticizers, sugar, demineralized water, pacifiers, dye, coloring that is edible, glycerin, and preservatives.

What are the Disadvantages of Hard Gelatin Capsules?

Hard gelatin capsules

 Hard gelatin capsules

There are several demerits of a hard gelatin capsule.

Below are some of them.

Liquid formulations and hygroscopic materials cannot be held in this type of capsule.

This is because the liquid creates holes in this capsule, and this may lead to leakage of the product.

The hard gelatin capsules are commonly made in a cylindrical shape, unlike the soft-gel capsules which are available in many shapes like round, oval, fish-like, among others.

This type of capsule can only disintegrate inside digestive fluids.

Other than this, it may become difficult to disintegrate.

The hard gelatin capsules must maintain specific water content.

If the water content drops to below 12 percent to 15 percent, they may begin to crack.

This may compromise their quality, and products held inside may start leaking out.

How long will Hard Gelatin Capsules take to Disintegrate in the Stomach?

Capsules disintegrating in stomach

Capsule disintegrating in stomach

Hard gelatin capsules may take a different time to disintegrate inside the stomach.

This time is influenced by the specific point you intended the drug to be released in.

It will also be determined by the number of plasticizers used while manufacturing the empty capsules.

Nevertheless, the approximate disintegration time can range from three to thirteen-minute from the time the capsule is swallowed.

This is because some of them contain enteric coating, which prevents them from dissolving in an acidic environment.

What are Empty Capsules Defects?

Hard gelatin capsules defects

Hard gelatin capsules defects

The process of manufacturing capsules may be compromised at some point resulting in defects on the capsules.

Empty capsules have many defects, and these include:

Defect in shape: These may be a dent, mashed, short, and long, double cap, or bent capsules.

All these defects may compromise the filling of the recommended quantity of the powder into the empty capsules.

Defect on color: Some capsules may be discolored, have a varied color or different color from what was intended.

This may confuse the medicine during administering, and therefore such defects must be rejected before capsule filling.

Defect on the appearance of the capsules: The capsule with this kind of defect will appear different.

They may have foreign particles attached to them, scrap, edge, dirt, split, hole, cracked, or a telescopic surface.

This may become difficult to swallow.

Printed mark defect: This is evident when the printed marks are not of good quality or when the mark is completely missing.

This may make the identification of the capsule content difficult for the users.

What are the Benefits of Empty Vegetable Capsules?

  • They are good for everyone, regardless of religion. It is also recommended for many people since there is no fear of allergy or diet. The vegetable is good for all.
  • They are easy to digest since it does not interfere with your normal digestion.
  • Vegetable capsules do not cause any effect of a person’s skin like other types of capsules. Even persons with sensitive skin may not feel any itchiness on their skin after taking it.
  • In addition to these, this capsule has a great taste, unlike gelatin, which is bitter. It is, therefore, suitable for those who have a fear of taking bitter capsules.

What is Acid Resistant Empty Capsules?

These are special capsules that cannot disintegrate in the stomach.

They are made with an enteric coating that helps in delaying the release of the drug.

This feature prevents dissolution in the gastric environment in the stomach.

The active ingredient is then released in the duodenum so that they can be absorbed in the intestines.

Acid resistant capsule

 Acid resistant capsule

Acid-resistant capsules are ideal for delivering enzymatic and probiotic formulations.

Apart from the delayed-release, these type of capsules is not different from hard gelatin capsules or two-piece capsules.

Therefore, we have both acid-resistant gelatin and vegetable capsules.

What makes Hard Gelatin Capsules Acid Resistant?

Hard gelatin capsules can be acid-resistant because they have an enteric coating.

This coating helps in delaying the release of the capsule content in the stomach.

When should you use Acid Resistant Capsules?

Acid-resistant capsules should be used when you want to hold drugs that should be released in the duodenum.

The medicine should pass through the stomach without being released, but upon reaching the duodenum, it should be released.

These are medicine contents that are supposed to be released in a duration of between 3 to 13 minutes.

The timing should be from the time the drug is swallowed.

Are Empty Capsules Safe?

Yes, they are. Empty capsules made from vegetable or gelatin are all safe.

Their safety greatly depends on the choice of ingredients and the condition under which they are stored.

To be sure that the empty capsules are safe, look at the manufacture’s adherence to the stipulated quality standards.

What are Empty Capsules Quality Standards?

There are many quality standards you should know about empty capsules. These include:

  • The KO and OU Kasher requirements.
  • The vegetarian and vegan Action society Guidelines
  • The certification from Halal
  • The FDA requirements
  • The European medical agency requirement
  • European pharmacopeia
  • United States pharmacopeia
  • Japanese pharmacopeia
  • The European Directorate for Quality medicine

The safety of vegetable capsules is ensured through strict adherence to all the above quality standards.

Apart from these, the capsule filling process must also maintain the same quality standards.

How do Clear Empty Capsules compare to Empty Colored Capsules?

Clear vs colored empty capsules

 Clear vs colored empty capsules

Clear empty capsules are transparent.

When they are filled with some products, you can see the content even when the capsule is sealed.

They are colorless.

On the other hand, empty colored capsules have been made with some pigment or color.

Some may be colored but transparent, and you can see the content inside when it is filled.

However, some of the colored empty capsules are opaque.

Such are not transparent, and when filled, you may not see the content inside.

Why use Custom Printed Empty Capsules?

Customized printed empty capsules are good for many reasons.

You can personalize the products with your logo, dosage, or any other desired information.

It can also be used for proper identification of the different sizes of the empty capsules.

For example, you could customize the big and small sizes, which are size 000 and 5, respectively.

The color of the empty capsules can also be customized.

For instance, Pantone color in both gelatin and HPMC based capsules can be matched.

Also, customization can allow you to produce pearlescent color.

Empty Capsules can also be produced in many custom flavors.

This is interesting because these wide ranges of flavors have a relatively delicious taste and smell.

Unpleasant odor or taste can be covered by a custom flavor, and this can give you a better competitive edge.

What should you consider when buying Empty Capsules?

Empty capsules are normally useful in holding herbs, powder, and medicines.

There are many issues to look at when you want to buy empty capsules.

These include:

  • The capsules should be Kosher and Halal certified. This means they must be gelatin, vegetarian, or enteric capsules.
  • It shouldn’t have GMO Certification apart from the vegetarian capsules, which sometimes can be made with this kind of compliance.
  • All the capsule caps should not contain any preservatives.
  • They should be gluten-free.
  • The gelatin capsules should pose 100% bovine hide.
  • Both vegetarian and enteric caps should be made with HPMC.
  • The dissolution speed should vary. Gelatin capsules should dissolve normally, and vegetarian one should dissolve at a medium rate. The enteric capsule should dissolve slowly.
  • Another factor worth considering is the size of the capsules. The sizes that are available are 000, 00, 00E, 0E, 0,1,2,3,4,5

What is the Structure of Two-Piece Capsules?

Structure of two piece empty capsules

 Structure of two piece empty capsules

The structure of the two-piece capsule consists of the head and the body.

The body is longer and a little bit less broad in comparison to the head.

This means that the body can be inserted into the head, leaving some overlapping parts of the body.

The body gets filed with products while the head caps the body after filling.

Therefore, the volume of the body acts as the normal volume filling.

Which types of Empty Capsules are used in the Pharmaceutical Industry?

Many types of empty capsules are being used in pharmaceutical industries. These include:

· Empty Vegetable Capsules

These are empty capsules made from vegetable cellulose that has been extracted from plants.

They are ideal for people who are allergic to animal products.

Those who consume them are very comfortable since they don’t have to worry about anything.

These capsules are free from starch and are preferred by many consumers.

· Empty Gelatin Capsules

These are empty capsules made from gelatin that has been extracted from animal products.

They are ideal for use in pharmaceutical industries since they have been made in compliance with the GMP.

They also have Kosher and Halal certification.

These types of capsules are good for those who do not have any side effects when they take animal products.

Unfortunately, individuals who experience some problems when they take animal products may react negatively when given gelatin capsules.

· Empty Acid Resistant Vegetable Capsules

These are empty vegetable capsules that have a unique characteristic of resisting disintegration in the stomach acid.

The vegetable acid-resistant capsules can only allow dissolution in neutral media.

They are ideal for acid-sensitive formulations like probiotics and enzymes.

They also have lower moisture content and are therefore ideal for hygroscopic materials.

These types of capsules are free from allergy and gluten, non-GMO, and preservative-free.

Empty acid-resistant vegetable capsules have been made in compliance with Kosher and Halal certified regulations.

These capsules are available in different sizes from 00, 0, 1, 2, 3, 4, and 5.

Lastly, acid-resistant vegetable capsules are made in compliance with US Patent 945214.

· Acid Resistant Gelatin Capsules

These are gelatin capsules that contain an enteric coating that helps in delaying the release of drugs in the stomach.

These capsules have been manufactured from 100 percent bovine hide gelatin.

The capsule resists disintegration in the stomach but is released in the duodenum.

The acid-resistant gelatin capsule is relevant in pharmaceutical applications because it protects the ingredients from stomach acid.

These types of capsules are cost-effective since costly enteric coating process is not necessary.

They also enhance capsule appeal through different colors and printing options.

In addition to these, they have very low moisture content, and this makes them good for moisture-sensitive formulations.

Apart from these, they are cross-linking resistant and stable in a wide range of temperatures and humidity.

They are also available in different sizes.

For example, size 000, 00, 0, 1, 2, 3, 4, and 5.

Lastly, they have global regulatory acceptance.

· Empty HPMC Capsules

These are empty capsules manufactured from hydroxypropyl methylcellulose.

Globally, they are called hypromellose.

The material for making this type of empty capsules is extracted from plant cellulose.

Initially, it was the first alternative for vegetarians.

This material became famous in the early 2000s since it offered a relatively stable polymer that has low moisture content.

This made it a preferred material for moisture-sensitive ingredients.

Apart from this, it’s highly resistant to both heat and humidity, especially when they are above the average.

How do you achieve Low Dose Capsule Filling?

A low dose capsule filling can be achieved by using a dosator capsule filling machine.

This machine has a nozzle that can fill doses that are as low as between 5 to 20mg.

This is made possible by making some adjustments to the machine nozzle.

This machine nozzle can be manipulated to make it much smaller than the normal one.

The diameter can be reduced, and this alteration ends up changing the overall machine performance.

The low dose filling of capsules helps in making the machine performance more predictable and easy to scale.

Secondly, it guarantees an efficient production output, and therefore, it is ideal for large scale production.

Low dose capsule filling can even be achieved with an automated machine that is integrated with other existing systems.

The achievement is made possible because the machine is accurate and precise, and its production process is enhanced.

Many technologies have been tried, but industries have realized that dosator technology is the best for low fill weight capsules.

In summary, I believe this guide answers all your questions on empty capsules.

Still, if you need more clarifications on any type of empty capsules, don’t hesitate to contact SaintyCo.

Gel-Caps Gelatin Capsule 100% bovine hide gelatin

Gel-Caps Gelatin Capsule 100% bovine hide gelatin

Gel+-Caps Gelatin Capsule Acid Resistant Capsules

Gel+-Caps Gelatin Capsule acid resistant capsules for enteric drug.

Veg-Caps Vegetable Capsule

Veg-Caps Vegetable Capsule Made from hypromellose* – cellulose derived from trees

Veg+-Caps Vegetable Capsule Acid Resistant Capsules

Veg+-Caps Vegetable Capsule Acid Resistant Capsules for enteric drug.

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